Coadministration of natural compounds, such as curcumin (CUR), enhanced CIS apoptotic activity on CIS-resistant lung adenocarcinoma cells through the inhibition of FANCD2 mono-ubiquitination and inactivation of the Fanconi anemia (FA)/BRCA pathway, which is a DNA cross-link damage repair pathway responsible for cellular resistance regulation towards DNA cross-link agents [172]. The gene discussed is FANCD2; the disease is Friedreich ataxia.