Wang et al. synthesized polymeric micelles composed of PEG, polyethyleneimine (PEI) blocks, and ATP-depleting Pluronic P123 bound together with a disulfide bond and loaded with PTX- and siRNA-targeting polo-like kinase1 (PLK1) that acts in downregulation of ATP and interferes with the cancer cell metabolism. This evidence concerns the gene PLK1 and cancer.