What is known in human IBD is that MLN HLA-DR+ SIRPa+ DC-like mononuclear phagocytes drive the emergence of a dual Th1/Th17 phenotype in MLN central memory T-cells, while both DC-like and macrophage-like mononuclear phagocytes amplify the MLN Th17 responses [40]. Here, SIRPA is linked to inflammatory bowel disease.