TGFB1 and colitis: TGF-beta-1 overexpression in non-differentiated DCs of DSS colitis mice upregulates T-regs in MLNs that delay the disease progression, whereas in differentiated DCs it promotes effector T-cell trafficking from MLNs to the colonic mucosa by upregulating the expression of the gut homing integrin α4β7, leading to colitis induction [30,31].