In recent work by our group, we showed that increased and sustained activation of the DDR and PARP1 signaling pathways contributes to ectopic calcification in the rare Mendelian disorder PXE, and that DDR inhibition by the PARP1 inhibitor minocycline could significantly counteract soft tissue mineralization in PXE cells and our abcc6−/− zebrafish model [12]. This evidence concerns the gene PARP1 and Pseudoxanthoma elasticum.