To confirm the physiological role of eIF4G1 phosphorylation at Ser1147 in the initiation step of protein translation and elucidate whether this phosphorylation could be a target to recover brain regions vulnerable to ischemia, further studies would be needed to assess the implications of this phosphorylation in the survival/death balance in brain tissue under IR stress. The gene discussed is EIF4G1; the disease is ischemia.