Interestingly, but contradictory, a reduction in the eIF4E/eIF4G1 complex in the CA1 region in R3d samples (Figure 3B and Figure 4B) was associated with a relative increase in the phosphorylation at Ser1147 in the eIF4G1 bound to eIF4E (Figure 3D and Figure 4D), the brain region that was vulnerable to ischemia and where translation inhibition was not recovered after IR [11]. The gene discussed is EIF4G1; the disease is ischemia.