To evaluate the cytokine profile and to identify the differential activation of the inflammatory pathways in familial Mediterranean fever (FMF), TNF-receptor associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), Blau syndrome (BS), and NLRP12 deficiency (NLRP12D), we used a protein array-based system with high sensitivity. The gene discussed is NLRP12; the disease is TNF receptor 1-associated periodic fever syndrome.