Although the latest studies on SPDL1 missense variant in relation to the pathology of idiopathic pulmonary fibrosis (IPF) [19,20] and cancer protection [19] have suggested the association of SPDL1 with cell senescence, our bioinformatic analyses did not confirm this result, at least with regard to CRC, as we found SPDL1 to be positively correlated with, e.g., MKI67 (coding for marker of cell proliferation, Ki-67) and TRA2B, KIAA1524, PRC1, SKP2 (coding for anti-senescence factors [21,22,23]), but not with the key senescence promoting genes. This evidence concerns the gene PRC1 and cancer.