Furthermore, we did not detect any marked differences in clinicopathological features of patients whose tumors exhibited SPDL1 overexpression compared to the remainder of the cohort, the presence of which would be expected with the protein acting as a tumor suppressor; though tumors with SPDL1-low expression tended to show more frequent perineural invasion; however, the difference was not statistically significant. Here, SPDL1 is linked to neoplasm.