In the multivariate Cox model, SPDL1 (HR = 0.42, 95% CI 0.23–0.78, p = 0.006), tumor grade (HR = 3.87, 95% CI 1.36–11.01, p = 0.01), pM stage (HR = 3.32, 95% CI 1.73–6.37, p = 0.0003), resection margin (HR = 2.37, 95% CI 1.13–4.98, p = 0.02) were found to be independent prognostic factors predicting OS of CRC patients (Table 2). The gene discussed is SPDL1; the disease is neoplasm.