SPDL1 and colorectal carcinoma: Moreover, Kodama and coworkers termed SPDL1 a candidate CRC tumor suppressor, primarily based on functional studies in CRC cell lines and their xenograft models in nude mice with SPDL1 manipulation, as well as the adverse survival of SPDL1 (mRNA)–low expressing CRC patients (TCGA data from GEPIA; n = 109) [10].