Patients with WDSTS which have KMT2A pathogenic variants have a distinct epigenetic signature in peripheral blood from a variety of other NDDs, including syndromes that may clinically overlap with WDSTS, like Kabuki type 1 patients with KMT2D pathogenic variants or Kabuki1 episignature (Figure 4). This evidence concerns the gene KMT2D and Wiedemann-Steiner syndrome.