Moreover, in glioblastoma cells, OSMR serves as an essential co-receptor for EGFRvIII—a truncated, active form of epidermal growth factor receptor—and its silencing or pharmacological inhibition of the EGFRvIII-OSMR interaction suppressed Stat3 activation, cell proliferation, and tumor growth [112]. The gene discussed is OSMR; the disease is glioblastoma.