Epithelial to mesenchymal transition (EMT) of tumor cells facilitates their migration and invasiveness, and stromal cells, such as cancer associated fibroblasts (CAFs) and cancer associated adipocytes (CAAs) significantly contribute to the malignant phenotype in the primary and secondary sites by releasing specific signals [39], which include the IL-6 family of cytokines [40]. Here, IL6 is linked to cancer.