Other ways to decrease IFN signaling and pro-inflammatory cytokine induction in tumor cells, therefore limiting TAM recruitment, includes administration of rapamycin to block integrin beta 1 receptors [98], which are expressed on the cell surfaces of macrophages [99]; pretreatment with the histone deacetylase inhibitor valproic acid [100]; or administration of cellular communication network factor 1 (CCN1) antibodies [101,102,103]. This evidence concerns the gene CCN1 and neoplasm.