CIDEC and obesity due to melanocortin 4 receptor deficiency: Interestingly, the influence of cricket extract on obesity was also evident in genes involved in lipogenesis and lipid accumulation, including leptin, adiponectin, acetyl-CoA carboxylase (ACC), fat-specific protein 27 (Fsp27) and peroxisome proliferator-activated receptor gamma (PPAR-γ), which were downregulated [96].