In addition, cluster 0 expressed Serpinf1, involved in ossification and osteoblast differentiation [59], Hsd11b1, shown to exacerbate atherosclerosis [60], Pex5l, expressed in macrophages [61] and Gfra2 in monocytes [62], as well as cystatin C, associated with coronary artery calcification [63] (Figure 5a,b and Supplementary Figure S4a). The gene discussed is SERPINF1; the disease is atherosclerosis.