Interestingly, genes associated with cardiovascular disease mortality (Clec3b [40]), as well as VSMC transdifferentiation such as Igfbp6 [48] and Dpep1 [49], were upregulated in AA&R versus DT aorta-derived cells of Apoe−/− mice, independently of the diet (Supplementary Figure S3b,d), implying that these genes may be key determinants in atherosclerotic site-specific predisposition. The gene discussed is IGFBP6; the disease is cardiovascular disorder.