In addition, to reveal the relevance of cathepsin X activity with respect to proteolytic processing of γ-enolase in GBM tissues, the protein levels of the total and the intact active form of γ-enolase were determined in GBM tissue lysates, and the effect of the peptide mimicking the intact C-terminal end of γ-enolase on GBM cell, macrophage, and microglia proliferation was assessed. This evidence concerns the gene CTSZ and glioblastoma.