Namely, in a mouse model of Alzheimer’s disease, the C-terminally cleaved form of γ-enolase was associated with cathepsin X in the immediate plaque vicinity, whereas the intact active form was observed in close proximity of the senile plaque, with preferential localization in microglia, which are the resident immune cells in the brain [40]. This evidence concerns the gene CTSZ and early-onset autosomal dominant Alzheimer disease.