Wang and his collaborators used Human Kidney (HK-2) cells and mice with unilateral ureteral obstruction (UUO) and tested novel tetracyclic triterpenoid compounds (PZC, PZD, and PZE), in which they act on the inhibition of the RAS, TGF-β/Smad, and Wnt/β-catenin signaling. The gene discussed is TGFB1; the disease is Ureteral obstruction.