Olmesartan, candesartan, and telmisartan administration into mice with collagen-induced arthritis, which is a mouse model of human rheumatoid arthritis, diminished lymphocyte proliferation and IFN-gamma production in vitro assays, and suppressed antigen-specific Th1 and Th2 lymphocytes in vivo. Here, IFNG is linked to rheumatoid arthritis.