FKBP4 and Alzheimer disease: Indeed, we recently demonstrated that FKBP52 deficiency impairs autophagy facilitating Tau accumulation during Tau-induced proteotoxic stress in a human neuronal cell line and in TauP301S dorsal root ganglion neurons, suggesting that the decrease of FKBP52 detected in AD neurons might be relevant to the progression of the tauopathy [61].