IL1R1 and Alzheimer disease: The soluble IL-1R1 circulating form, sIL-1R1, together with the pro-inflammatory cytokines IL-1α and IL-1β, the antagonist IL-1Ra and the accessory receptor sIL-1RAcP, were shown to be elevated in the serum samples of subjects with AD, contrasting with the levels verified in patients with subjective memory complaints (SMC) and mild cognitive impairment (MCI).