The soluble IL-1R1 circulating form, sIL-1R1, together with the pro-inflammatory cytokines IL-1α and IL-1β, the antagonist IL-1Ra and the accessory receptor sIL-1RAcP, were shown to be elevated in the serum samples of subjects with AD, contrasting with the levels verified in patients with subjective memory complaints (SMC) and mild cognitive impairment (MCI). The gene discussed is IL1A; the disease is Cognitive impairment.