Of these, the main ones are Cu, Zn superoxide dismutase 1 (SOD1), TAR DNA binding protein 43 (TARDBP), fused in sarcoma (FUS) and chromosome 9 open reading frame 72 (C9orf72), responsible for 5–10% of ALS cases [18,98]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.