In particular, elevated levels of IL-1β were detected in chronic active lesions and CSF samples of MS patients [70,71,72,111,112] and in animal models of experimental autoimmune encephalomyelitis (EAE)—an autoimmune model particularly used to study myelin demyelination, neuroinflammation and immune system activation [113,114]. This evidence concerns the gene IL1B and myeloid sarcoma.