Pandey et al. found that the mRNA levels of IL-1R1, IL-6, TNF-α, TNFR1 and TNFR2 were significantly increased in lymphocytes of schizophrenia patients compared with control subjects, suggesting that these pro-inflammatory players may be useful biomarkers or targets for therapeutic approaches [143]. This evidence concerns the gene IL1R1 and schizophrenia.