PTK2 and neoplasm: Furthermore, Diaz Osterman et al. found the elevation of FAK Tyr397 phosphorylation in non-necrotic residual tumor bispies from HGSOC patients who received preoperative (neoadjuvant) carboplatin and paclitaxel chemotherapy and in cisplatin-resistant ovarian cancer A2780 and OVCAR10 cells compared with lower FAK levels in the parental cells [194].