The inhibition of FAK through the ectopic expression of antisense oligonucleotides or carboxyl-terminal domain of FAK (FAK-CD) results in the loss of adhesion and the promotion of anoikis in cancer cells, which is mediated by the Fas-associated death domain (FADD) and the caspase-8-mediated proapoptotic pathway [74,75]. Here, PTK2 is linked to cancer.