PTK2 and neoplasm: FAK was initially identified as a component of the integrin-mediated signaling axis [5,6], and growing evidence indicated that FAK is involved in the regulation of diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, angiogenesis, and the establishment of an immunosuppressive tumor microenvironment (TME) through kinase-dependent and -independent scaffolding functions in both the cytoplasm and nucleus [7,8,9,10].