This complex process involves the transition of tumor cells to a motile phenotype mediated by intracellular changes in focal adhesion dynamics and cytoskeleton rearrangement; the loss of E-cadherin during EMT to promote motile traits; the upregulation of matrix metalloproteinases (MMPs) to facilitate ECM invasion; and extracellular changes in ECM remodeling [93,94]. Here, CDH1 is linked to neoplasm.