We found that T1D reduced the F-actin sliding velocity and the NTF maximum velocity over myosin in the in vitro motility assay for all regions (p ≤ 0.0004, Figure 7A, Table 1), which was accompanied by an increase in the β-MHC isoform content (LV: p = 0.0162, IS: p = 0.030, RV: p = 0.0441, Figure 7B). Here, MYH14 is linked to type 1 diabetes mellitus.