BRCA1 and neoplasm: Notably, 79% (49 out of 60 patients with ovarian cancer) did not harbor tumor BRCA1 or BRCA2 (tBRCA) mutations, and 53% had a negative HRD status based on the assay from Myriad Genetics, but the clinical benefits of this combination were apparent regardless of tBRCA mutation or HRD status.