Parallelly, a mutation in the Cytochrome P450 Family 2 Subfamily U member 1 (SPG56/CYP2U1) at 4q25 leads to early onset of spasticity in the lower body parts, aiding in walking disabilities by inhibiting the P450 hydroxylase enzyme activities, causing loss of protein structure, leading to ataxia, retina impairment, and neuropathy [64]. The gene discussed is CYP2U1; the disease is cerebellar ataxia.