AP5Z1 and Cognitive impairment: The 7p22.1 mutation in Adaptor Related Protein Complex 5 Subunit Zeta 1 (SPG48/AP5Z1), facilitating intracellular transmembrane proteins sorting and trafficking cargos through vesicles, results in motor and sensory neurons neuropathy, ataxia, parkinsonism, and cognitive impairments [71].