In 2004 Meijer reported 10q22.1-q24.1 region is associated with the HSP phenotype due to homozygous mutation, and through atlasgeneticsoncology.org (accessed on 15 October 2021), we discovered the adenosine kinase (SPG27/ADK) is located in the region, and focused study on this gene might elucidate HSP pathophysiology. The gene discussed is ADK; the disease is hereditary spastic paraplegia.