Furthermore, 14q32.31 contains a potential HSP pathogenic variant, the tectonic beta-propeller repeat-containing 2 (SPG49/TECPR2) necessary for degrading proteins (autophagy) to maintain the cellular viability and homeostasis, and discrepancy in this mechanism is the foundation for a wide range of muscular and neurodegenerative disorders, including HSP [91]. This evidence concerns the gene CYP2U1 and hereditary spastic paraplegia.