Calebin A (CA) [4-(3-methoxy-4-hydroxyphenyl)-2-oxo-3-enebutanyl 3-(3-methoxy-4-hydroxyphenyl) propenoate], a non-curcuminoid active component obtained from the rhizome of turmeric (Curcuma longa L., Zingiberaceae) [47,48] is described to possess anti-inflammatory, anti-tumor and anti-oxidant properties [47,49,50,51], whereby many of these studies identified a significant suppressing effect of CA on the activation of the pro-inflammatory NF-κB pathway. This evidence concerns the gene NFKB1 and neoplasm.