EphB4 was also found to promote the Rac/c-Raf pathway in mamma carcinoma, Akt and mTor were downstream targets of EphB4 in ovarian cancer, Integrin β8 was regulated in prostate carcinoma, and notch signaling was epigenetically upregulated by EphB4 in colorectal cancer, suggesting a pro-tumorigenic role [39,40,41,42]. This evidence concerns the gene EPHB4 and colorectal cancer.