VEGFA and endothelial dysfunction: Moreover, since VEGF/sFlt-1 unbalance is widely accepted as the main trigger for the endothelial dysfunction, leading to hypertension in preeclampsia [52,53,54], we hypothesize that PDMSCs-CM counteracted endothelial dysfunction in our LPS-induced PE model via pro-angiogenic VEGF modulation and anti-angiogenic sFlt-1 inhibition.