The latter cytokine is the main responsible for the profile shifting of antigen-activated T cells from a T helper (Th) 2 toward a Th1 cytotoxic phenotype [10].Various studies demonstrated the anti-tumor potential of HP-NAP due to its activity as a modulator of the adaptive immune response [11,12,13], but the possibility that HP-NAP might counteract tumor growth due to the modulation of mononuclear cells, regardless of the participation of the adaptive immunity, remained unexplored. The gene discussed is CTNNBL1; the disease is neoplasm.