MPEG1 and neoplasm: To further substantiate the role of macrophages in HP-NAP-induced tumor clearance, we repeated the above experimental set up in Tg(mpeg1:eGFP)gl22 fishes depleted for most macrophage population through the administration of Liposome-Clodronate (L-CLO), which targets macrophages regardless of their embryonic origin [19].