Expression of PD-1 and PD-L1 on CD14+ monocytes significantly declined after 2 months of anti-TB treatment (PD-1, 32.2 ± 31.2% vs. 18.9 ± 16.98%, p = 0.006; PD-L1, 39.2 ± 27.9% vs. 20.7 ± 23.4%, p < 0.001). Here, CD274 is linked to tuberculosis.