A large cross-sectional study investigated the association of CRP levels and psychological distress mediated by antidepressants in 10,363 UK adults, found robust associations of log-CRP and General Health Questionnaire (GHQ) among antidepressant users but not for non-users in both cross-sectional (p = 0.01 vs. 0.06, p = 0.28) and longitudinal models (p = 0.006 vs. 0.04, p = 0.39 two waves post-baseline) [60]. Here, CRP is linked to Abnormal emotional state.