MFRP and retinal degeneration: Likewise, mouse models with mutations in Mfrp, including rd6 (4 bp deletion) [2], rdx (174delG mutation) [12], and a c.498_499insC knock-in [13], show phenotypic similarities to the human diseases such as hyperopia, reduced axial length, retinal degeneration, RPE atrophy, and decreased electrophysiological response.