Whereas Sanchez-Mut et al. [27] and Wang et al. [42] have clearly shown that the presence of the minor allele A in rs708727 alters the methylation of the PM20D1 promoter (and, thus, its expression) in a dose-dependent (quantitative) manner, the best-fitting genetic models in our study indicate that the presence of one rs708727 A allele is sufficient to alter the susceptibility to the onset of PD. This evidence concerns the gene PM20D1 and Parkinson disease.