GLA and Fabry disease: Fabry disease (FD) is a rare, inherited, lysosomal storage disease caused by mutations in the GLA gene, which manifests as a lack, or significant deficiency, of the lysosomal enzyme α-galactosidase A (α-GAL A), leading to the accumulation of globotriaosylceramide (GL-3) within lysosomes in different cell types, including endothelial cells, podocytes, and cardiomyocytes [92].