TP53 and colorectal carcinoma: Therefore, we studied the synthesized sirtinol derivative, MHY2245 [2-(naphthalen-1-yl)-2,3-dihydroquinazolin-4(1H)-one] (Figure 1) [29], and investigated its effects on cell cycle regulation, induction of apoptosis, and DNA damage response in HCT116 [wild-type (WT) TP53], HT-29 (mutant TP53), DLD-1 (mutant TP53) human CRC cells, and NCM460D (an epithelial cell line from a normal human colon).