To determine the effects of MHY2245 on the growth of CRC cells (HCT116, HT-29 and DLD-1) with different p53 types, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was performed. The gene discussed is TP53; the disease is colorectal carcinoma.