Modulation of TMEM16A by extracellular H+ could be important in pathophysiological conditions, since changes in pHo occur during cellular injury, ischaemia, or tumour progression [196] in the brain [197], retina [198,199,200], or epithelial cells [201,202,203,204,205,206,207], where CaCC channels are expressed [17,46,208]. This evidence concerns the gene CLCA2 and neoplasm.