AP2B1 and cancer: TMEM16G may also interact with proteins upregulated during cancer progression [75], including the cellular vesicles staphylococcal nuclease and tudor domain-containing 1 (SND1), the heat shock protein family A (Hsp70) member 1A (HSPA1A), the adaptor-related protein complex 2 subunit beta 1 (AP2B1), and the coatomer protein complex subunit gamma 2 (COPG2); however, the functional significance of these interactions remains undefined [76].