Previous studies using several different models of obesity, including leptin-deficient ob mice, leptin receptor-deficient db mice, and mice fed a HFD, have indicated that obesity increases numbers of myeloid-committed progenitor cells, including multipotent progenitors (MPPs), common myeloid progenitors (CMPs), and granulocyte and macrophage progenitors (GMPs) [59,60,61,62,63]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.