PTGS2 and cancer: These are the leading causes of many other conditions other than cancer, such as inflammation [115,116,117], and flavonoids target different receptors to modulate intracellular signaling pathways involved also in this process like SIRT1, nuclear factor kappa B (NF-κB), mitogen activated protein kinases (MAPKs) and cyclooxygenase-2 (COX-2) [118,119,120,121].