Most of all, expression of HTR2B was found to positively respond to the STAT protein inducers IL-4 and IL-6, a mechanism ensured at least in part through the −280 STAT DRE, thereby further supporting the existence of an interleukin/JAK/STAT signalization pathway that may contribute to the metastatic properties of uveal melanoma. The gene discussed is HTR2B; the disease is uveal melanoma.