ELN and pulmonary emphysema: The elastin 3D organization is fundamental to guarantee that applied forces are efficiently transmitted from the alveoli to all parts of the lung [4]; therefore, defective production, altered fibre assembly and/or increased degradation are responsible for increased susceptibility to lung diseases (i.e., emphysema, Cutis laxa, bronchopulmonary dysplasia, chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS)).