The elastin 3D organization is fundamental to guarantee that applied forces are efficiently transmitted from the alveoli to all parts of the lung [4]; therefore, defective production, altered fibre assembly and/or increased degradation are responsible for increased susceptibility to lung diseases (i.e., emphysema, Cutis laxa, bronchopulmonary dysplasia, chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS)). Here, ELN is linked to chronic obstructive pulmonary disease.