Therefore, it was important to study the effects of different levels of DLK2 expression on the growth of MDA-MB-231 breast cancer cells and their tumorigenic properties, and then compare them with the effects exerted by DLK1 in these cells, especially since NOTCH signaling was found to be a hallmark of triple-negative breast cancer tumors [36]. Here, DLK2 is linked to breast carcinoma.