In this regard, previously published data show that the inhibition of NOTCH signaling led to an increase in E-cadherin expression and a decrease in the invasive capacity of MDA-MB-231 cells [43], which agrees with our findings showing that HDLK2SH cells exhibit a high rate of inhibition of NOTCH1 activation and prevent tumor development in nude mice. The gene discussed is NOTCH1; the disease is neoplasm.