Within a period of 1 to 2 months, most cases of flare resolve, but some have a more protracted course, and repeated [12,13], sustained (≥ 6 months) [14], or severe (with alpha-fetoprotein (AFP) levels greater than 100 ng/mL and/or bridging hepatic necrosis) flare episodes are more frequently associated with the development of cirrhosis [13]. The gene discussed is AFP; the disease is Cirrhosis.