CD8A and Hepatitis: HBV-specific CD8+ T cells are crucial for suppressing viral replication, and HBV flares are associated with the expansion and activation of HBV-specific memory cells; notably, more HBV core antigen 18-27-specific CD8+ T cells (c18-27-CD8Ts) were detected in HBeAg-negative CHB patients than in HBeAg-positive CHB patients, and hepatitis flares were found to be closely associated with the expansion of c18-27-CD8Ts [138].