RIPK3 and acute kidney injury: RIPK3 also promoted fibrosis in a 28-day folic acid nephropathy model, suggesting a role of this protein in AKI–CKD transition; however, it is not clear whether this effect of RIPK3 is dependent on the necroptosis pathway [52], as bone marrow-derived RIPK3 mediates kidney inflammation in AKI independently from necroptosis [53].