A study using a murine HCC model has revealed that MMP10 was activated through the MAPK/ERK pathway and C-X-C chemokine receptor-4/stromal-derived factor-1 (CXCR4/SDF1) axis has contributed to hepatocellular cancer progression and metastasis [67]. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.