ALB and age-related macular degeneration: These products cause protein modification, resulting in the accumulation of defective proteins that can be recognized by the complement system as “foreign.” It can be assumed that such functionally important proteins as serum albumin and hemoglobin, when modified with water-soluble A2E photooxidative destruction products, can activate the complement system, initiate inflammation, and lead to the development of AMD upon prolonged exposure to cells.