Conversely, the genes CD2, EMR3, CARD15, EV12A, HLA-DP1, IFNG, IL2, ITK, KLK10, LAT, MPO, PSCA, PTHLH, PTHR1, RUNX3, and TNFSF8 have been found hypomethylated in 25 primary melanomas, compared with 29 benign nevi [39]. This evidence concerns the gene RUNX3 and melanoma.