Interestingly, distinct hypermethylated genes have been found associated with genetic mutation subgroups, e.g., NF1 hypermethylation with NF1- and RAS-mutated melanomas, PTEN hypermethylation with BRAF-mutated, and CDK2A/B hypermethylation with BRAF-, RAS-, NF1-mutated and triple-WT melanomas [40]. The gene discussed is PTEN; the disease is melanoma.