Overexpression of either SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) or suppressor of variegation 3–9 homolog 1 (SUV39H1), both enzymes methylating histone H3 on lysine 9 (H3K9), significantly accelerates melanoma formation [22]. This evidence concerns the gene SUV39H1 and melanoma.