A recent study has shown that, when PANX1 is overexpressed in rhabdomyosarcoma (RMS), both RNA sequencing and co-immunoprecipitation coupled to high performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ES-MS) reveal that PANX1 interacts with many cytoskeleton-associated proteins physically [60]. Here, PANX1 is linked to rhabdomyosarcoma.