Aside from the limited number of samples used and the donors’ individual biological variability, including the wall-to-lumen ratio in groups of control rats, it is notable that the two arteriosclerotic patients shared in common: (1) a severe endothelial dysfunction as judged by the measurements of nitrite/nitrate ratio level relative to the healthy artery homogenate [41,42], and (2) a dramatic reduction in the arterial content of sirtuin-1 levels. Here, SIRT1 is linked to endothelial dysfunction.