The association between WNK3 mRNA expression and cellular responsiveness to several clinically established anticancer drugs and the prognostic value of WNK3 mRNA expression with the survival times of sarcoma patients can be taken as clues that CSA-based inhibition of WNK3 might improve treatment outcomes of cancer patients and that CSA may serve as a valuable supplement to the currently used combination therapy protocols in oncology. The gene discussed is WNK3; the disease is cancer.