Patients with lacunar strokes present a pro-thrombotic state, demonstrated by overall increased plasma levels of tissue plasminogen activator (TPA), plasminogen activator inhibitor (PAI), fibrinogen, and D-dimer, compared to patients without stroke, but lower levels, compared to other stroke subtypes, characterized by larger infarct volumes [38,74]. The gene discussed is SERPINB2; the disease is stroke disorder.