Furthermore, in NHL cell lines, rituximab inhibits the overexpressed transcription repressor Yin Yang 1 (YY1), which suppresses Fas and DR5 expression, leading to sensitization to Fas ligand and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis [16]. The gene discussed is TNFSF10; the disease is non-Hodgkin lymphoma.