STAT1 signaling as and NF-κB were also shown as activated by polysaccharides isolated from the root of Ilex asprella (IAPS-2) or from Lachnum (a sort of mushroom) promoting secretion of anti-tumor cytokines by TAM and increasing animal survival rate in a sarcoma mouse model [163,164]. This evidence concerns the gene STAT1 and neoplasm.