Tognon et al. [160] reported deregulation of the extrinsic apoptotic pathway in the leukocytes of patients with MPN: FAS, C-FLIP and TRAIL levels were increased in PV, anti-apoptotic gene FAIM was increased in PMF, while DR5 expression was decreased in ET patients (Table 2). The gene discussed is FAS; the disease is myeloproliferative disorder.