FAS and myeloproliferative disorder: To summarize, observed dysregulation of neutrophil apoptosis in MPN was expressed as an up-regulation of both anti-apoptotic (C-FLIP, CORO1A) and pro-apoptotic (S100, PYCARD, FAS, TRAIL) factors, as well as down-regulation of pro-apoptotic (BID, BIM, DR5) factors (Table 2).