JAK2 and myeloproliferative disorder: Therefore, genomic instability in MPN neutrophils and/or their precursor and progenitor cells, can evolve as a direct consequence of: (1) constitutive JAK2-mediated signaling [169]; (2) JAK2V617F kinase related prevention of DNA damage-induced apoptosis by inappropriate regulation of cell survival pathways [168]; (3) defective DNA-repair as their cell-intrinsic characteristic [59,60,61].