Although presently we do not have any proof to refer to of possible overexpression of MCL-1 in MPN neutrophils, it has been shown that GM-CSF induced activation of STAT3 signaling, in cooperation with PI3K, is implicated in Mcl-1 upregulation and delayed apoptosis in normal human neutrophils [159]. This evidence concerns the gene MCL1 and myeloproliferative disorder.