[131] Rabbits with T1D mellitus induced by alloxan injection and analyzed at six weeks after induction of diabetes manifest an increase in the oxidated proteins and lipids, a decrease in enzymatic activity (catalase, glutathione peroxidase and superoxide dismutase), and a decline in p-PI3K/PI3K, p-AKT/AKT and p-GSK3/GSK3 ratios [132]. Here, AKT1 is linked to diabetes mellitus.